Biostatistical Analysis on Synergetic therapy of the three plants

Abstract

The liver is an important metabolic organ consisting of four different sized lobes in our bodies. Theimportant function of liver includes the elimination of toxic material, detoxication and regulationof theblood, blood clotting, and manufacture of vital hormones. It also plays a crucial role in other activities, such as pathogen protection, synthesis of bile salts, food supply, and blood collecting. There is currentlyno obvious mechanism that includes direct hepatotoxicity and unfavorable immune response for several
study reports on hepatic damage mechanisms. Pharmaceutical bioactivation creates reactive chemical
metabolites that interact with lipids, nucleic acid, and proteins in the cell, producing DNAdamage, protein malfunction, lipid peroxidation, and oxidative stress. Many illnesses also affect the liver due toitsstrategic position. Hepatotoxins, due to the overdose of drugs, xenobiotics, alcohol, and industrial toxins, can harm the liver. However, Natural and synthetic chemicals are used to treat liver diseases ashepatoprotective agents. This study was conducted to was conducted to evaluate the hepatoprotectivepotential of Geranium Wallichianum, Elaeagnus Parvifolia and Taraxacum Of icinale against carbontetrachloride (CCl4) induced hepatotoxicity in experimental rats. Extract of all three plants was induced(200mg/kg) and combination of all three plants was given in (100mg/kg). liver enzymes including alanineaminotransferase (ALT) and aspartate aminotransferase (AST), alkaline phosphatase (ALP) andtotal
bilirubin as well as liver histopathology were evaluated to see the effect of herbal treatments. Results of
this study suggest that all three plants have hepatoprotective effect and highest effect was notedinSynergetic therapy